CARBENICILLIN DISODIUM

PRODUCT IDENTIFICATION
CAS NO. 4697-36-3 (Base)
4800-94-6 (Disodium)

CARBENICILLIN DISODIUM

EINECS NO. 225-360-8, 225-360-8
FORMULA C17H16N2O6S·Na2
MOL WT. 422.36

H.S. CODE

  

TOXICITY

  
SYNONYMS Geocillin; Geopen; Pyopen;

(2S,5R,6R)-6-(2-carboxylate-2- phenylacetamide)- 3,4-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate, disodium salt;

SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellowish powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH 6.5 - 8.0
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT  
STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS
· Penicillin: Any of a large group of broad-spectrum antibiotic drugs derived directly or indirectly from molds of the genus Penicillium and other soil-inhabiting fungi grown on special culture media, which exert a bacteriocidal as well as a bacteriostatic effect on susceptible bacteria during their growth stage by the inhibition of biosynthesis of their cell wall mucopeptide. Penicillin, beta-lactam antibiotics, possess a four-ring beta-lactam structure shares a nitrogen and a carbon atom with fused a five-membered thiazolidine ring. These antibiotics have low toxicity for the host but effective against most gram-positive bacteria including pathogens (streptococci, staphylococci, pneumococci); clostridia; some gram-negative gonococci; some spirochetes (Treponema pallidum and T. pertenue); and some fungi. Certain strains of some target species, e.g., staphylococci, secrete the enzyme penicillinase, which inactivates penicillin and confers resistance to the antibiotic.

· Carbenicillin: Carboxybenzylpenicillin antibiotic effective against gram-negative bacteria (such as susceptible strains of Pseudomonas species, Proteus species, Escherichia coli, and Haemophilus influenzae) and gram-positive pathogens. It is administered intramuscularly or intravenously as it is poorly absorbed from the gastrointestinal tract. It is an analog to ampicillin.

· Carbenicillin disodium: the disodium salt of carbenicillin; slightly yellow powder; freely soluble in water; administered intramuscularly or intravenously. The chemical designation is (2S,5R,6R)-6-(2-carboxylate-2- phenylacetamide)- 3,4-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate, disodium salt.

· Carindacillin sodium (Carbenicillin indanyl sodium): the sodium salt of the indanyl ester of carbenicillin; administered orally. The chemical designation is 1-(5-Indanyl)-N-(2-carboxy-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo[3.2.0] hept-6-yl)-2-phenylmalonamate monosodium salt.

· Carfecillin sodium (Carbenicillin phenyl sodium) : the sodium salt of the phenyl ester of carbenicillin.
SALES SPECIFICATION

APPEARANCE

 yellowish powder

IDENTIFICATION

pass
POTENCY

770 (µg/mg), Anhydrous basis
OPTICAL ROTATION +186° ~ +199°

WATER

6.0% max
TRANSPORTATION
PACKING  
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 42/43, Safety Phrases: 22-36/37